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This new research is quite intriguing and it has some important implications for consideration of the proposed FDA tobacco legislation being promoted by Philip Morris and by a number of major anti-smoking groups. The results of the research are not intuitive; in fact, they may seem unexpected to those who were not previously familiar with the existing research showing in vitro, nicotine exhibits some suppressive effects on platelet activity. These new findings, which demonstrate this effect in vivo, suggest that the proposed FDA legislation may end up harming the public’s health not only because a reduction in nicotine levels may lead to increased tar delivery due to compensation, but also because greatly reduced nicotine cigarettes may be more pro-thrombotic and therefore more dangerous.

The purpose of this research was apparently to evaluate the health effects of new low- and zero-nicotine cigarettes being marketed by Vector Group (Quest cigarettes). The research shows that despite having very low or no nicotine, these cheapcigarettes may not be safer for smokers, and that they may in fact be more hazardous due to reduction of the platelet activation suppression function of nicotine.

Although not the primary purpose of the research, it also has important implications for the evaluation of a government-mandated reduction in nicotine levels in cigarettes. The research cautions us that a strategy of mandating reductions in the nicotine content of cigarettes could be harmful to smokers, and therefore in conflict with the goal of protecting the public’s health.